The Journal of Organic Chemistry

Chemical synthesis of some mono-and digalactosyl O-glycopeptides

JM Lacombe, AA Pavia

Index: Lacombe, J. M.; Pavia, A. A. Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2557 - 2563

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Citation Number: 51

Abstract

Chemical syntheses of several 0-glycopeptides containing 0-galactosylthreonine are reported. Two different approaches have been investigated to determine the strategy best adapted to the synthesis of any desired 0-glycopeptide. Glycosylation of an adequately protected threonine-containing peptide was shown to be less successful than a stepwise strategy using an appropriate 0-glycosyl amino acid as starting material. This route was ...