Highly Enantioselective Asymmetric Isomerization of Primary Allylic Alcohols with an Iridium–N, P Complex

JQ Li, B Peters, PG Andersson

Index: Li, Jia-Qi; Peters, Byron; Andersson, Pher G. Chemistry - A European Journal, 2011 , vol. 17, # 40 p. 11143 - 11145

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Abstract

The asymmetric transformation of allylic amines to optically active enamines, catalyzed by rhodium-BINAP complexes, has been well studied and even applied in industry.[1] The related transition-metal-catalyzed isomerization of primary allylic alcohols is an atom- economical route to the corresponding aldehydes (Scheme1). Various catalysts have been developed for this reaction,[2] however, only a few asymmetric examples have been ...