Artificial Multi??Enzyme Networks for the Asymmetric Amination of sec??Alcohols

…, J Pitzer, D Pressnitz, D Koszelewski…

Index: Tauber, Katharina; Fuchs, Michael; Sattler, Johann H.; Pitzer, Julia; Pressnitz, Desiree; Koszelewski, Dominik; Faber, Kurt; Pfeffer, Jan; Haas, Thomas; Kroutil, Wolfgang Chemistry - A European Journal, 2013 , vol. 19, # 12 p. 4030 - 4035

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Citation Number: 30

Abstract

Abstract Various artificial network designs that involve biocatalysts were tested for the asymmetric amination of sec-alcohols to the corresponding α-chiral primary amines. The artificial systems tested involved three to five redox enzymes and were exemplary of a range of different sec-alcohol substrates. Alcohols were oxidised to the corresponding ketone by an alcohol dehydrogenase. The ketones were subsequently aminated by employing a ω- ...