Tetrahedron: Asymmetry

A biocatalytic one-pot oxidation/reduction sequence for the deracemisation of a sec-alcohol

CV Voss, CC Gruber, W Kroutil

Index: Voss, Constance V.; Gruber, Christian C.; Kroutil, Wolfgang Tetrahedron Asymmetry, 2007 , vol. 18, # 2 p. 276 - 281

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Citation Number: 17

Abstract

Biocatalytic deracemisation via inversion of rac-2-decanol was accomplished by a combined oxidation/reduction sequence using the same 'single'catalyst for both steps. Overall, the (R)- alcohol was inverted to the corresponding (S)-alcohol. Lyophilised cells of various Rhodococci spp. were tested for the unselective oxidation of the racemic sec-alcohol using acetone as the hydrogen acceptor in the first step. For the second step, the stereoselective ...