Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: Discovery of a novel neuroinflammation inhibitor

YX Yang, LT Zheng, JJ Shi, B Gao, YK Chen…

Index: Yang, Ya-Xi; Zheng, Long-Tai; Shi, Jing-Jing; Gao, Bo; Chen, Yan-Ke; Yang, Hui-Chi; Chen, Hong-Li; Li, Yuan-Chao; Zhen, Xue-Chu Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1222 - 1227

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Citation Number: 9

Abstract

Abstract Glial activation-mediated neuroinflammation plays a pivotal role in the process of several neuroinflammatory diseases including stroke, Alzheimer's diseases, Parkinson's diseases, multiple sclerosis and ischemia. Inhibition of microglial activation may ameliorate neuronal degeneration under the inflammatory conditions. In the present study, a number of 5α-cholestan-6-one derivatives were prepared and the anti-inflammatory effects of these ...