Anticancer activity of ruthenium (II) arene complexes bearing 1, 2, 3, 4-tetrahydroisoquinoline amino alcohol ligands

…, MK Sokhela, T Govender, HG Kruger…

Index: Chelopo, Madichaba P.; Pawar, Sachin A.; Sokhela, Mxolisi K.; Govender, Thavendran; Kruger, Hendrik G.; Maguire, Glenn E. M. European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 407 - 414

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Citation Number: 17

Abstract

Abstract Ruthenium complexes offer potential reduced toxicity compared to current platinum anticancer drugs. 1, 2, 3, 4-tetrahydrisoquinoline amino alcohol ligands were synthesised, characterised and coordinated to an organometallic Ru (II) centre. These complexes were evaluated for activity against the cancer cell lines MCF-7, A549 and MDA-MB-231 as well as for toxicity in the normal cell line MDBK. They were observed to be moderately active ...