Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process

X Florence, S Dilly, P De Tullio, B Pirotte…

Index: Florence, Xavier; Dilly, Sebastien; De Tullio, Pascal; Pirotte, Bernard; Lebrun, Philippe Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 13 p. 3919 - 3928

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Citation Number: 5

Abstract

Abstract The synthesis of different series of 4-and 6-substituted R/S-3, 4-dihydro-2, 2- dimethyl-2H-1-benzopyrans is described. All of these new benzopyran derivatives were bearing, at the 4-position, a phenylthiourea moiety substituted on the phenyl ring by a meta or a para-electron-withdrawing group such as Cl or CN. The study aimed at exploring the influence of the nature of the substituent at the 6-position in order to develop new ...