The low affinity PCP sites in the rat cerebellum not only bind TCP-like but also BTCP-like structures

…, J Hamon, H Hirbec, J Vignon, JM Kamenka

Index: Espaze, Florence; Hamon, Jacques; Hirbec, Helene; Vignon, Jacques; Kamenka, Jean-Marc European Journal of Medicinal Chemistry, 2000 , vol. 35, # 3 p. 323 - 331

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Citation Number: 6

Abstract

Congeners of the potent dopamine (DA) re-uptake inhibitor 1-[1-(2-benzo [b] thiophenyl) cyclohexyl] piperidine (BTCP) are unexpectedly able to bind in the rat cerebellum, although this structure is devoid of dopaminergic nerve endings. In line with previous studies the hypothesis that they bind to low affinity PCP sites labelled with [3H] TCP in the rat cerebellum, even though they do not bind to the high affinity PCP sites in the forebrain, ...