Preparation of novel azabicyclic amines and α7 nicotinic acetylcholine receptor activity of derived aryl amides

DP Walker, BA Acker, E Jon Jacobsen…

Index: Walker, Daniel P.; Acker, Brad A.; Jacobsen, E. Jon; Wishka, Donn G. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 247 - 257

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Citation Number: 6

Abstract

Azabicyclic alkanes are important building blocks in drug discovery. Several drug substances possessing an azabicyclic alkane moiety, including sabcomeline [1], varenicline [2], granisetron [3] and cevimeline [4] have been launched (Chart 1). In addition, numerous reports on biologically active substances containing an azabicyclic alkane have appeared in the literature, with an emphasis towards CNS-related targets, such as serotonin 5-HT3 ...