Synthesis and Spectroscopic Characterization of Photo??affinity Peptide Ligands to Study Rhodopsin–G Protein Interaction

…, R Herrmann, N Fishkin, P Henklein…

Index: Chen, Yihui; Herrmann, Rolf; Fishkin, Nathan; Henklein, Peter; Nakanishi, Koji; Ernst, Oliver P. Photochemistry and Photobiology, 2008 , vol. 84, # 4 p. 831 - 838

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Citation Number: 4

Abstract

Abstract G protein-coupled receptors (GPCRs) are involved in the control of virtually all aspects of our behavior and physiology. Activated receptors catalyze nucleotide exchange in heterotrimeric G proteins (composed of α· GDP, β and γ subunits) on the inner surface of the cell membrane. The GPCR rhodopsin and the G protein transducin (G t) are key proteins in the early steps of the visual cascade. The main receptor interaction sites on G t are the ...