An Efficient and Enantioselective Synthesis of Suitably Protected β??[1??(4??Malonyl) naphthyl]??L??alanine and β??[1??(4??Malonylmethyl) naphthyl]??L??alanine: Novel …

…, JP Luzy, N Gresh, C Garbay

Index: Chen, Huixiong; Luzy, Jean-Philippe; Gresh, Nohad; Garbay, Christiane European Journal of Organic Chemistry, 2006 , # 10 p. 2329 - 2335

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Citation Number: 7

Abstract

Abstract Molecular dynamics simulations based on the structure of the Grb7 SH2 domain in complex with the ErbB2 phosphorylated peptide pTyr1139 have suggested that β-[1-(4- malonyl) naphthyl]-L-alanine (L-mNal) may be accommodated in the pTyr binding pocket and offer additional beneficial interactions. Therefore, this compound and its analog β-[1-(4- malonylmethyl) naphthyl]-L-alanine (L-mmNal), which are newnon-hydrolysable ...