Tetrahedron

First functionalization by metallation of the pyridine moiety of pyridopyrimidin-4 (3H)-ones. Diazines. Part 36

J Audoux, N Plé, A Turck, G Quéguiner

Index: Audoux, Jerome; Ple, Nelly; Turck, Alain; Queguiner, Guy Tetrahedron, 2004 , vol. 60, # 18 p. 4107 - 4123

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Citation Number: 13

Abstract

Starting from o-aminopyridine carboxylic acids, a general synthetic route leading to various pyridopyrimidin-4 (3H)-ones is described. The first metallation and functionalization of the pyridine moiety has been studied and a regioselective metallation at the peri-position C5 of the pyridine ring has been highlighted.