The synthesis, distribution, and anti-hepatic cancer activity of YSL

…, Z Shen, Y Sun, G Lin, C Wang, M Zhao, S Peng

Index: Ding, Wenfeng; Zhang, Jiali; Yao, Zhi; Lu, Rong; Wu, Dezhu; Li, Ginfu; Shen, Zilong; Sun, Yingji; Lin, Gang; Wang, Chao; Zhao, Ming; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4989 - 4994

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Citation Number: 14

Abstract

YSL was prepared stepwise from C terminal to N terminal with the side chain un-protective amino acids, Boc-Leu-OMe, Boc-Ser-OH, and Boc-Tyr-OH, as the starting materials in 39.5% total yield (31.2 g/per batch). With the side chain un-protective Boc-(3, 5-dibromo)-Tyr-OH and HCl· Ser-Leu-OMe as the starting materials (3, 5-3H-Tyr)-Ser-Leu-OH was obtained in 29% yield. The determination of radioactive quantity in the urine and feces indicated that ...