Journal of heterocyclic chemistry

Synthesis of indole derivatives from N??alkenyl??o??chloroanilines with zero??valent nickel complex

JG Rodriguez, L Canoira

Index: Rodriguez, J. G.; Canoira, L. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 883 - 888

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Citation Number: 12

Abstract

Abstract Reaction of N-alkenyl-o-chloroanilines in toluene with tetrakis (triphenylphosphine) nickel (0) was carried out mainly to give indole and indoline derivatives in good yields. A detailed analysis of the reaction products has been done and it allows us to confirm the postulated mechanism of the cyclization reaction. Torsional hindrance around the N [BOND] C [BOND] Csp 2 bond seems to prevent the cyclization reaction.