Microwave-assisted efficient synthesis of 2-hydroxydeoxybenzoins from the alkali degradation of readily prepared 3-aryl-4-hydroxycoumarins in water

ZZ Zhou, GH Yan, WH Chen, XM Yang

Index: Zhou, Zhong-Zhen; Yan, Guang-Hua; Chen, Wen-Hua; Yang, Xue-Mei Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 11 p. 1166 - 1172

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Abstract

This paper describes an operationally simple, green and efficient approach for the synthesis of 2-hydroxydeoxybenzoins bearing diverse substituents from the microwave-assisted alkali degradation of 3-aryl-4-hydroxycoumarins in water. The latter compounds were readily prepared from the intramolecular Claisen condensation reaction of methyl 2-(2-arylacetoxy) benzoates in the presence of Cs 2 CO 3–acetone, in excellent yields and without ...