Bulletin of the Chemical Society of Japan

The ruthenium catalyzed synthesis of quinoline derivatives from nitroarenes and aliphatic alcohols

Y Watanabe, Y Tsuji, J Shida

Index: Watanabe; Tsuji; Shida Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 2 p. 435 - 438

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Citation Number: 33

Abstract

Nitroarenes are reductively converted into quinoline derivatives with aliphatic alcohols in the presence of a catalytic amount of ruthenium compound at 180° C. Ruthenium (III) chloride is the most effective catalyst. The reaction of nitrobenzene with 1-propanol and 1-butanol gave 2-ethyl-3-methylquinoline and 3-ethyl-2-propylquinoline in 65 and 70% yields respectively. p-Methoxynitrobenzene gave 3-ethyl-6-methoxy-2-propylquinoline in 70% yield with 1- ...