Synthesis and cardiotonic activity of esters of 2-substituted 5-cyano-1, 6-dihydro-6-oxo-3-pyridinecar☐ ylic acids. Crystal structure of 2-methyl, 2-t-butyl and 2-phenyl …

…, P Schenone, P Dorigo, RM Gaion, F Benetollo…

Index: Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529

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Citation Number: 38

Abstract

Abstract The synthesis of ethyl and methyl esters of 2-substituted 5-cyano-1, 6-dihydro-6-oxo- 3-pyridinecar☐ ylic acids by reaction of ethyl or methyl 2-dimethylaminomethylene-3- oxoalkanoates with sodium cyanoacetamide is described. These esters gave by alkaline hydrolysis the corresponding car☐ ylic acids, which were decar☐ ylated to 6-substituted 1, 2- dihydro-2-oxo-3-pyridinecarbonitriles.

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Novel Hepatitis C virus replicon inhibitors: Synthesis and s...

[Chris Krueger; Madigan, Darold L.; Beno, David W.; Betebenner, David A.; Carrick, Robert; Green, Brian E.; He, Wenping; Liu, Dachun; Maring, Clarence J.; McDaniel, Keith F.; Mo, Hongmei; Molla, Akhteruzzaman; Motter, Christopher E.; Pilot-Matias, Tami J.; Tufano, Michael D.; Kempf, Dale J. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2212 - 2215]