Tetrahedron Letters

Transition-metal-free approach to synthesis of indolines from N-(ortho-chloromethyl) aryl amides and iodonium ylides

H Huang, Y Yang, X Zhang, W Zeng, Y Liang

Index: Huang, Hui; Yang, Yuan; Zhang, Xiaoyun; Zeng, Weilan; Liang, Yun Tetrahedron Letters, 2013 , vol. 54, # 45 p. 6049 - 6052

Full Text: HTML

Citation Number: 7

Abstract

Indolines are important building blocks in a vast number of biologically active natural products 1 and pharmacologically active compounds. 2 The synthesis of this privileged structure has attracted significant interest and numerous synthetic methodologies have been developed for recent years. 3, 4, 5, 6, 7, 8, 9 and 10 Most of these approaches to construct indolines were focused on transition-metal-catalyzed C–N or C–C bond formation. 4 However, because of the ...