Tetrahedron letters

Microwave initiated reactions: Pechmann coumarin synthesis, Biginelli reaction, and acylation

MS Manhas, SN Ganguly, S Mukherjee, AK Jain…

Index: Manhas, Maghar S.; Ganguly, Subhendu N.; Mukherjee, Somdatta; Jain, Amit K.; Bose, Ajay K. Tetrahedron Letters, 2006 , vol. 47, # 14 p. 2423 - 2425

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Citation Number: 90

Abstract

An energy-efficient protocol has been developed for solvent-free reactions that are mildly exothermic but not spontaneous. The exothermic reaction mixture—on several g-scale—is exposed for about 30s to low power (about 200W) microwaves and then the microwave oven is switched off. After this short burst of energy, the exothermic reaction gets initiated and proceeds on its own to completion. A number of coumarins were synthesized by the ...