Hydroboration. 81. Synthesis of 2-(dialkylamino) boronic esters and acids via hydroboration of enamines. A convenient preparation of. beta.-dialkylamino alcohols

CT Goralski, B Singaram, HC Brown

Index: Goralski, Christian T.; Singaram, Bakthan; Brown, Herbert C. Journal of Organic Chemistry, 1987 , vol. 52, # 18 p. 4014 - 4019

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Citation Number: 34

Abstract

Hydroboration of representative enamines with 1 equiv of borane-dimethyl sulfide (BMS) in tetrahydrofuran affords as the major product the corresponding [2-(dialkylamino) alkyl] boranes, which are characterized by llB NMR spectroscopy. These intermediates on methanolysis give the corresponding [2-(diakylamino) alkyl] boronates. On treatment with water, these esters undergo rapid hydrolysis to provide the 2-[(dialkylamino) alkyl] boronic ...