e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
A convenient synthesis of N??aryl??1, 2??dihydro??2??oxo??3??pyridinecarbox??amides, N??aryl??N??methyl??1, 2??dihydro??2??oxo??3??pyridinecarboxamides and their 1??methyl ( …
C Cativiela, J Fernandez…
Index: Cativiela, C; Fernandez, J.; Melendez, E. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1093 - 1097
Abstract A new and versatile method for the preparation of the isonixine analogues, N-aryl-1, 2-dihydro-2-oxo-3-pyridinecarboxamides and N-aryl-N-methyl-1, 2-dihydro-2-oxo-3- pyridinecarboxamides is described via the selective chlorination of 2-hydroxynicotinic acid. In order to prepare these new compounds, the chemistry of the methyl-blocked forms of each tautomer is discussed.
