Molecules

Straightforward Synthesis of Novel 1-(2′-α-OD-Glucopyranosyl ethyl) 2-Arylbenzimidazoles

N Arumugam, AS Abdul Rahim, S Abd Hamid…

Index: Arumugam, Natarajan; Rahim, Aisyah Saad Abdul; Hamid, Shafida Abd; Osman, Hasnah Molecules, 2012 , vol. 17, # 8 p. 9887 - 9899

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Citation Number: 7

Abstract

Abstract: A series of novel 1-(2′-α-OD-glucopyranosyl ethyl) 2-arylbenzimidazoles has been prepared via one-pot glycosylation of ethyl-1-(2'-hydroxyethyl)-2-arylbenzimidazole-5- carboxylate derivatives. Synthesis of the 2-arylbenzimidazole aglycones from 4-fluoro-3- nitrobenzoic acid was accomplished in four high-yielding steps. The reduction and cyclocondensation steps for the aglycone synthesis proceeded efficiently under ...