Synthesis, anti-HSV-1, and cytotoxic activities of some new pyrazole-and isoxazole-based heterocycles

KM Dawood, H Abdel-Gawad, HA Mohamed…

Index: Dawood, Kamal M.; Abdel-Gawad, Hassan; Mohamed, Hanan A.; Badria, Farid A. Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 912 - 919

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Citation Number: 15

Abstract

Abstract Ethyl 2, 4-dioxo-4-(p-chloro) phenylbutyrate 2 obtained by condensation of 4- chloroacetophenone with diethyl oxalate was converted to 5-(4-chlorophenyl)-1-phenyl-1 H- pyrazole-3-carbohydrazide 5 and 5-(4-chlorophenyl) isoxazole-3-carbohydrazide 6 in good yields. Treatment of 5 or 6 with phenylisothiocyanate and reaction of the resulting thiosemicarbazide 7 or 8 with chloroacetic acid and 4-fluorobenzaldehyde, phenacyl ...