Novel non-peptidic neuropeptide YY 2 receptor antagonists

…, P Bonaventure, TW Lovenberg, NI Carruthers

Index: Jablonowski, Jill A.; Chai, Wenying; Li, Xiaobing; Rudolph, Dale A.; Murray, William V.; Youngman, Mark A.; Dax, Scott L.; Nepomuceno, Diane; Bonaventure, Pascal; Lovenberg, Timothy W.; Carruthers, Nicholas I. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1239 - 1242

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Citation Number: 20

Abstract

Through SAR studies of a piperidinylindoline cinnamide HTS lead, the first potent, non- peptide, low molecular weight selective Neuropeptide Y Y2 (NPY Y2) antagonists have been synthesized. The SAR studies around the piperidinyl, the indolinyl, and the cinnamyl moieties are discussed.