Exploration of novel thiobarbituric acid-, rhodanine-and thiohydantoin-based HIV-1 integrase inhibitors

S Rajamaki, A Innitzer, C Falciani, C Tintori…

Index: Rajamaki, Suvi; Innitzer, Anna; Falciani, Chiara; Tintori, Cristina; Christ, Frauke; Witvrouw, Myriam; Debyser, Zeger; Massa, Silvio; Botta, Maurizio Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 13 p. 3615 - 3618

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Citation Number: 36

Abstract

A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity ...

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A Versatile and Practical Synthesis toward the Development o...

[Rinaldi, Marta; Tintori, Cristina; Franchi, Luigi; Vignaroli, Giulia; Innitzer, Anna; Massa, Silvio; Este, Jose A.; Gonzalo, Encarna; Christ, Frauke; Debyser, Zeger; Botta, Maurizio ChemMedChem, 2011 , vol. 6, # 2 p. 343 - 352]