Irreducible analogs of mevaldic acid coenzyme A hemithioacetal as potential inhibitors of HMG-CoA reductase. Synthesis of a carbon-sulfur interchanged analog of …

…, RH Turakhia, CJ Morrow

Index: Fischer, Gordon C.; Turakhia, Rajesh H.; Morrow, Cary J. Journal of Organic Chemistry, 1985 , vol. 50, # 12 p. 2011 - 2019

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Citation Number: 19

Abstract

II the latter approach. First, work by Lynen and co-workers3 has shown that mevaldic acid pantetheine hemithioacetal, 2b, is a substrate for the second reduction step, leading to 3 and 4b. However, it could not be shown that HMGS-pantetheine, lb, is a substrate for the first reduction step. s Second, there is, as yet, no evidence that a ketone can be reduced by the HMG-CoA reductase system. Third, there are a number of very potent competitive ...