might have been influenced by enhanced lipid solubility due to the presence of the hydrophobic l-methyl function. It was demonstrated earlier that the partition coefficient (PC) was unimportant for the radiosensitization of hypoxic Chinese hamster cells in vitro. 1 This conclusion was, however, based upon PCs of a large series of structurally unrelated nitroheterocyclic or nitroaromatic compounds. Employing a series of 2-nitroimidazoles, it ...
