Cyclic urea nucleosides. Cytidine deaminase activity as a function of aglycon ring size

…, JS Driscoll, RW Fuller, JJ McCormack

Index: Liu, Paul S.; Marquez, Victor E.; Driscoll, John S.; Fuller, Richard W.; McCormack, John J. Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 662 - 666

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Citation Number: 55

Abstract

Five@-Dribofuranosyl cyclic urea nucleosides (14-18), ranging in ring size from five to eight membered, were synthesized and evaluated as cytidine deaminase (CDA) inhibitors. The precursor protected nucleosides (9-13) were prepared by a condensation procedure utilizing persilylated ureas with a halo sugar under the specific catalytic activity of a HgO/HgBr, mixture which provided exclusively the P-anomers. Catalytic hydrogenation of ...