Tetrahedron

Synthesis of amino acid esters by papain

D Cantacuzene, F Pascal, C Guerreiro

Index: Cantacuzene, D.; Pascal, F.; Guerreiro, C. Tetrahedron, 1987 , vol. 43, # 8 p. 1823 - 1826

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Citation Number: 39

Abstract

A wide range of N-Boc-amino add esters were synthesized from N-Boc-amino acids and alcohol using papain as catalyst. Suitable biphasic reaction mixtures were found for most amino acids to achieve high yield of ester synthesis. With N-Boc-L-aspartic and glutamic adds only the a carboxyl group is esterified, without racemisation.