e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
An Efficient Synthesis of 5, 7-Dihydroxy-4-methylisobenzofuran-1 (3N)-one, a Metabolite of aspergillus flavus and a Key Intermediate in the Synthesis of Mycophenolic …
K Kobayashi, H Shimizu, M Itoh…
Index: Kobayashi; Shimizu; Itoh; Suginome Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 8 p. 2435 - 2437
An efficient new synthesis of 5, 7-dihydroxy-4-methylisobenzofuran-1 (3H)-one, a metabolite of aspergillus flavus and a key intermediate in the synthesis of mycophenolic acid, is reported. The new synthesis involves the preparation of 1, 2-dihydro-4, 6-dimethoxy-3- methylbenzocyclobuten-1-ol and a regioselective β-scission of alkoxyl radical generated from it with lead tetraacetate as the key steps.
