Chemo-and stereoselective synthesis of benzocycloheptene and 1-benzoxepin derivatives as α-sympathomimetic and anorexigenic agents

VK Tandon, KA Singh, AK Awasthi, JM Khanna…

Index: Tandon, Vishnu K.; Singh, Kunwar A.; Awasthi, Anoop K.; Khanna; Lal, Bansi; Anand, Nitya Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 11 p. 2867 - 2870

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Citation Number: 13

Abstract

The synthesis and pharmacological evaluation of cis-and trans-6-amino-6, 7, 8, 9-tetrahydro- 5H-benzocyclohepten-5-ols 4a–c and 5a–c and cis-and trans-4-amino-2, 3, 4, 5-tetrahydro- 1-benzoxepin-5-ols 4d–f and 5d–f were carried out. Chemo-and stereoselective synthesis of 5a–f was achieved by reduction of corresponding α-amino ketones 3a–f with LiAl (t-BuO) 3H. cis-4-Amino-2, 3, 4, 5-tetrahydro-1-benzoxepin-5-ol 4d and trans-4-amino-2, 3, 4, 5- ...