2H, 15N-substituted nitroxides as sensitive probes for electron paramagnetic resonance imaging

…, MA Makowsky, S Muralidharan, P Tsai…

Index: Burks, Scott R.; Bakhshai, Justin; Makowsky, Mallory A.; Muralidharan, Sukumaran; Tsai, Pei; Rosen, Gerald M.; Kao, Joseph P. Y. Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6463 - 6467

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Citation Number: 23

Abstract

Electron paramagnetic resonance imaging (EPRI) using nitroxides is an emergent imaging method for studying in vivo physiology, including O2 distribution in various tissues. Such imaging capabilities would allow O2 mapping in tumors and in different brain regions following hypoxia or drug abuse. We have recently demonstrated that the anion of 3-carboxy- 2, 2, 5, 5-tetramethyl-1-pyrrolidinyloxyl (2) can be entrapped in brain tissue to quantitate ...