Organic letters

Palladium-catalyzed, copper (I)-mediated coupling of boronic acids and benzylthiocyanate. A cyanide-free cyanation of boronic acids

Z Zhang, LS Liebeskind

Index: Zhang, Zhihui; Liebeskind, Lanny S. Organic Letters, 2006 , vol. 8, # 19 p. 4331 - 4333

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Citation Number: 112

Abstract

A new method for the synthesis of nitriles is described. As a complement to the classic cyanation of aryl halides using cyanide sources and a transition metal catalyst, the palladium-catalyzed cross-coupling of thiocyanates with boronic acids in the presence of copper (I) thiophene-2-carboxylate (CuTC) affords nitriles in good to excellent yields.