The Journal of Organic Chemistry

One-pot synthesis of N-(2-heteroaryl)-. alpha.-amino esters by the regiospecific 2-N-(. alpha.-alkoxycarbonyl) alkylation of 2-aminoazines and-azoles with glyoxals …

B Alcaide, J Plumet, MA Sierra

Index: Alcaide, Benito; Plumet, Joaquin; Sierra, Miguel A. Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3143 - 3147

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Citation Number: 12

Abstract

2-Amino heterocycles, including pyridine, diazine, andd azole derivatives, are readily converted into N-(2-heteroary1)-a-amino esters 4 in a one-pot sequence by reaction with glyoxals and alcohols in the presence of perchloric acid. In addition, the corresponding a- amino acids 5 are quantitatively obtained by acidic hydrolysis of compounds