Tetrahedron

Catalytic carbon–sulfur bond formation by amphoteric vanadyl triflate: exploring with thia-Michael addition, thioacetalization, and transthioacetalization reactions

CT Chen, YD Lin, CY Liu

Index: Chen, Chien-Tien; Lin, Yow-Dzer; Liu, Cheng-Yuan Tetrahedron, 2009 , vol. 65, # 50 p. 10470 - 10476

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Citation Number: 23

Abstract

A series of thiols have been examined as protic nucleophiles for Michael-type additions to α, β-unsaturated carbonyls as well as double nucleophilic condensations with aldehydes, ketones, and acetals catalyzed by amphoteric, water-tolerant vanadyl triflate under mild and neutral conditions. The newly developed C–S bond formation protocols were carried out smoothly in good to high yields in a highly chemoselective manner.