7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma

…, F Galleway, L Gowers, JC Gregory, DR Hannah…

Index: Buckley, George; Cooper, Nicola; Dyke, Hazel J.; Galleway, Fiona; Gowers, Lewis; Gregory, Joanna C.; Hannah, Duncan R.; Haughan, Alan F.; Hellewell, Paul G.; Kendall, Hannah J.; Lowe, Christopher; Maxey, Robert; Montana, John G.; Naylor, Robert; Picken, C. Louise; Runcie, Karen A.; Sabin, Verity; Tuladhar, Bishwa R.; Warneck, Julie B. H. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2137 - 2140

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Citation Number: 19

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4). ... We have prepared a series of novel PDE4 inhibitors in which the 3,4- ...