Solventless convenient synthesis of new cyano-2-aminopyridine derivatives from enaminonitriles

…, Z Belhadj, N Cheikh, N Choukchou-Braham, N Bar…

Index: Villemin, Didier; Belhadj, Zahira; Cheikh, Nawel; Choukchou-Braham, Noureddine; Bar, Nathalie; Lohier, Jean-Francois Tetrahedron Letters, 2013 , vol. 54, # 13 p. 1664 - 1668

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Citation Number: 15

Abstract

A synthesis of novel 4-substituted-3-cyano-2-aminopyridines using enaminonitriles and various primary amines was established under microwave irradiation and solvent-free conditions. Structures of the new compounds were characterized by IR, MS, 1H and 13C NMR data and the structure of 2-aminopyridine of the products was confirmed by X-ray analysis.