Spiro [4.5] and spiro [4.6] carboxylic acids: cyclic analogs of valproic acid synthesis and anticonvulsant evaluation

…, JA Moore, TB Zalucky, JM Nicholson…

Index: Scott; Moore; Zalucky; Nicholson; Lee; Hinko Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 413 - 417

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Citation Number: 37

Abstract

Spiro [4.5] decane-2-carboxylic acid (12a), spiro [4.5] decane-2, 2-dicarboxylic acid (1 la), spiro [4.6] undecane-2-carboxylic acid (12b), spiro [4.6] undecane-2, 2-dicarboxylic acid (llb), and spiro [4.6] undecane-2-acetic acid (13) were synthesized by an improved method and evaluated for anticonvulsant activity. These analogues were synthesized to evaluate the role of the carboxylic acid group as an essential substituent in valproic acid (di-n- ...