An Efficient, Scalable Process for Benzphetamine Hydrochloride

C Pramanik, K Bapat, A Chaudhari…

Index: Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Kulkarni, Mukund G.; Kolla, Rangarao; Sompalli, Srinivasarao; Tripathy, Narendra K.; Gurjar, Mukund K. Organic Process Research and Development, 2014 , vol. 18, # 4 p. 495 - 500

Full Text: HTML

Citation Number: 2

Abstract

Commercial manufacturing of benzphetamine hydrochloride along with its impurity profiling is disclosed. Deoxygenation of pseudoephedrine is reported with∼ 100% retention by shielding the amine group as its tert-butyl carbamate, which is very straightforward to eliminate at the end. Four unknown process-related impurities are isolated from the samples of final API and characterized on the basis of their NMR and mass spectral analysis. ...