Preparation of D-cycloserine and 13 C-labeled D-cycloserine

NC Thacker, J Molnár-Tóth, JL Miska…

Index: Thacker, Nathan C.; Molnar-Toth, Judit; Miska, Judy L.; Barletta, Raul G.; Takacs, James M. Heterocycles, 2012 , vol. 86, # 2 p. 1575 - 1582

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Abstract

Abstract D-Cycloserine (DCS), a second stage drug for the treatment of tuberculosis, is synthesized in 19.8% overall yield from DL-serine methyl ester. This synthetic route gives both enantiomers of cycloserine via a corrected and improved one pot resolution procedure using D-and L-tartaric acids. The route is used to synthesize a 13C-labeled derivative for use in biological studies.© 2012 The Japan Institute of Heterocyclic Chemistry.