Abstract 3-Cyano-4-methyl-1H-pyrrole (1) was prepared by a new Wittig procedure from simple, commercially available starting materials in four steps with an overall yield of 39%. Similarly,[1-15 N]-3-cyano-4-methyl-1H-pyrrole (1a) was prepared starting from [15 N]- phthalimide. In this synthesis, Wittig coupling was used to form the central C–C bond of intermediate 6, which has nitrile and methyl substituents. Upon deprotection and ...
