e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Kinetics and mechanism of nitrosation of toluene, o-xylene, and m-xylene in trifluoroacetic acid, or in acetic–sulfuric acid mixtures, under nitric oxide
JH Atherton, RB Moodie, DR Noble
Index: Atherton, John H.; Moodie, Roy B.; Noble, Darren R. Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 4 p. 699 - 705
The title reactions give good yields with m-xylene, and modest yields with toluene and o- xylene which are successfully directly nitrosated for the first time. The advantages of purging with nitric oxide are demonstrated and discussed. The kinetics have been successfully interpreted in terms of a mechanism in which both the aromatic substrate and the nitrosoaromatics form, reversibly, complexes with nitrosonium ion. The nitrosoaromatics ...