Anomalous Orientation in a Friedel-Crafts Ketone Synthesis1

D Papa, E Schwenk, A Klingsberg

Index: Papa; Schwenk; Klingsberg Journal of the American Chemical Society, 1946 , vol. 68, p. 2133

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Citation Number: 16

Abstract

We have found another example of meta substitution in thme Friedel-Crafts reaction of ethyl phenylacetate. and acetyl chloride. This reactipn was first. described by Klewitzs and later by Bor~ che,~ both of whom apparently obtained only the p-isomer. Our results with this synthesis are at variance with those reported in the literat. ure. Instead of obtaining a uniform, solid ethyl P-acetylphenylacetate, we obtained a mixture of about equal amounts ...