Acylcarnitine analogues as topical, microbicidal spermicides.

PS Savle, GF Doncel, SD Bryant, MP Hubieki…

Index: Savle, Prashant S.; Doncel, Gustavo F.; Bryant, Stephen D.; Hubieki, M. Patricia; Robinette, R. Graham; Gandour, Richard D. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2545 - 2548

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Citation Number: 17

Abstract

Acylcarnitine analogues,(+)-6-Carboxylatomethyl-2-alkyl-4, 4-dimethylmorpholinium (Zn, where n= the number of carbons in the alkyl chain), synthesized in multi-gram quantities show in vitro activities as spermicides, anti-HIV agents, and inhibitors of the growth of Candida albicans. Activity improves with increasing chain length. Compound Z-15 is a candidate for further study as a topical, microbicidal spermicide.