Polyethylene Glycol (PEG 300) and Water–Ethanol as Benign Solvent Systems for the Synthesis of a Novel Series of 2-Hydroxynaphthalen-1 (4 H)-Ones

…, N Choukchou-Braham, B Mostefa-Kara

Index: Villemin; Benabdallah; Choukchou-Braham; Mostefa-Kara Synthetic Communications, 2010 , vol. 40, # 20 p. 3109 - 3118

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Citation Number: 2

Abstract

An improved, clean, simple, and efficient method for the synthesis of new series of 2-hydroxy- 4-methylenenaphthalen-1 (4H)-one is described. This new process involves a domino Michael addition of various methylene acid compounds with the sodium salt of 1, 2- naphthoquinone-4-sulfonate either in basic (t BuOK) polyethylene glycol (PEG300) at room temperature or in a basic (NaOH) water–ethanol medium at 40° C by a crushing in a ...