Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats

S Waidyanatha, PH Lin…

Index: Waidyanatha, Suramya; Lin, Po-Hsiung; Rappaport, Stephen M. Chemical Research in Toxicology, 1996 , vol. 9, # 3 p. 647 - 653

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Citation Number: 38

Abstract

Five cysteinyl adducts (including one with multiple isomeric forms) of hemoglobin (Hb) and albumin (Alb) have been characterized in the blood of Sprague-Dawley rats following administration of pentachlorophenol (PCP). Three of these adducts were formed by multiple substitution reactions of tetrachloro-1, 4-benzoquinone (Cl4-1, 4-BQ) and its products, and two arose from reactions of tetrachloro-1, 4-benzosemiquinone (Cl4-1, 4-SQ) and ...