Tetrahedron: Asymmetry

The first asymmetric syntheses of l-homocysteine and l-homocystine

M Adamczyk, JR Fishpaugh, M Thiruvazhi

Index: Adamczyk, Maciej; Fishpaugh, Jeffrey R.; Thiruvazhi, Mohan Tetrahedron Asymmetry, 1999 , vol. 10, # 21 p. 4151 - 4156

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Citation Number: 4

Abstract

Asymmetric syntheses of l-homocysteine 1 and l-homocystine 2 are described. Alkylation of the carbanion derived from Schöllkopf reagent 3 and ensuing hydrolyses gave S- triphenylmethyl-l-homocysteine 6. Removal of the triphenylmethyl group gave l- homocysteine 1 and subsequent oxidation provided l-homocystine 2.