Synlett

A mild, highly efficient, and chemoselective deprotection of trityl ethers of carbohydrates and nucleosides using iodine monobromide

S Malik, KPR Kartha

Index: Malik, Satish; Kartha, K. P. Ravindranathan Synlett, 2009 , # 11 p. 1809 - 1811

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Citation Number: 6

Abstract

Abstract Iodine monobromide in dichloromethane-methanol or acetonitrile constitutes an effective reagent for the deprotection of O-trityl and O-dimethoxytrityl ethers of carbohydrates and nucleosides. Acid-labile functionalities (acetals, Op-methoxybenzyl ethers, etc.) as well as base-labile groups (esters and amides) are stable under these conditions; and the method has been found to be superior to the hitherto known literature methods.