Amino alcohols of acetylene series. Part XI. Synthesis and cholinolytic properties of 1-phenyl-1-cycloalkyl-4-dialkylamino-2-butyn-1-ols

…, SI Loktionov, SN Golikov, BP Pashkevich…

Index: Libman, N. M.; Kuznetsov, S. G.; Loktionov, S. I.; Golikov, S. N.; Pashkevich, B. P.; Zatsepin, E. P. Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 12 p. 644 - 648 Khimiko-Farmatsevticheskii Zhurnal, 1998 , vol. 32, # 12 p. 21 - 25

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Abstract

Investigation of the properties of cholinolytics belonging to different structural groups showed that compounds having a cycloalkyl substituent at the carbinol carbon atom exhibit higher activity and lower toxicity than their diaryl analogs [1]. In the previous communications we have described several amino butynols [2, 3] and amino pentynols [4] containing cyclohexyl or cyclopentyl groups, but their pharmacological properties were characterized ...