A convenient and inexpensive synthesis of labelled methylmalonic and propionic acids: application to the synthesis of methyl??d3??malonic and of propionic??3, 3, 3??d3 …

P Allevi, A Longo, M Anastasia

Index: Allevi, Pietro; Longo, Alessandra; Anastasia, Mario Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 11 p. 1085 - 1091

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Citation Number: 3

Abstract

Abstract A synthetic route for obtaining highly pure methylmalonic and propionic acids labelled at the methyl groups is validated by the preparation of methyl-d 3-malonic and propionic-3, 3, 3-d 3 acids. The synthesis involves the alkylation of the diethyl allylmalonate with iodomethane-d 3, deallylation of the resulting diethyl allylmethyl-d 3-malonate by treatment with (η 2-propene) Ti (Oi-Pr) 2 and hydrolysis. Decarboxylation of the obtained ...